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KMID : 1134820090380020136
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Journal of the Korean Society of Food Science and Nutrition
2009 Volume.38 No. 2 p.136 ~ p.141
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Investigation of Biological Activities of Enzymatic Hydrolysate of Spirulina
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Son Min-Hee
In Man-Jin
Park Keun-Hyoung
Chae Hee-Jeong
Yoo Gui-Jae
Choi A-Reum
Kim Dong-Ho
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Abstract
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Biological activities of enzymatic hydrolysate of spirulina (EHS) were investigated. EHS showed no significant effects on the growth-stimulating activity for lactic-acid bacteria and antioxidant activity. EHS showed slight in vitro growth-inhibitory effects (15% at 1.42 mg/L) on a human cervical cancer cell line (HeLa). In addition, the anticoagulant activities of EHS were measured based on three different pathways: common, intrinsic and extrinsic pathways. As an indication of anticoagulant activity on common pathway, thrombin time (TT) of EHS (100 mg/L) was measured as 155.6 sec. Activated partial thromboplastin time (aPTT) for intrinsic pathway of EHS (1,000 mg/L) was measured as 95.8 sec. Prothrombin time (PT) based on extrinsic pathway of EHS (1,000 mg/L) was measured as 10.6 sec. These data showed that EHS have influences on anticoagulant factors of common pathway and intrinsic pathway. Consequently it was found that EHS could be used as a functional food for blood circulation.
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KEYWORD
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spirulina hydrolsate, biological activity, anticoagulant activity
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